2-Bromopyridine → 2-fluoro-N-(2-pyridyl)acetanilide

HRID 1977663

Reaction equation

HRID 1977663 reaction equation
[F:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4].Br[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1>>[F:1][CH2:2][C:3]([N:5]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:4]

Participants

3

Reactant 2

HCID 79732-BromopyridineHCID 95042-Fluoro-N-phenylacetamide

Product 1

HCID 219935112-fluoro-N-(2-pyridyl)acetanilideYield 75.2%

Procedure

Using 2-fluoroacetanilide (4.6 g) and 2-bromopyridine (9.5 g), a reaction was made in the same manner as in 1) of Production Example 14. The subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate:hexane=1:1.5) produced 2-fluoro-N-(2-pyridyl)acetanilide (5.2 g, crude product) as a red oil.

Workup

  1. customThe subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate:hexane=1:1.5)

Sources & evidence

ORD record
ord-742831b86bf34a6ca0b650a7d420922f
Source dataset
uspto-grants-2001_05
Patent number
US06235730B1

Linked notes

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