2-Phenoxy-4-(4-formylpiperazino)pyrimidine → 2-Phenoxy-4-piperazinopyrimidine

HRID 1979945Notes

Reaction equation

HRID 1979945 reaction equation
[O:1]([C:8]1[N:13]=[C:12]([N:14]2[CH2:19][CH2:18][N:17](C=O)[CH2:16][CH2:15]2)[CH:11]=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.Cl>[O:1]([C:8]1[N:13]=[C:12]([N:14]2[CH2:15][CH2:16][NH:17][CH2:18][CH2:19]2)[CH:11]=[CH:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 138695712-Phenoxy-4-(4-formylpiperazino)pyrimidine

Product 1

HCID 138695632-Phenoxy-4-piperazinopyrimidineYield 64%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

2-Phenoxy-4-(4-formylpiperazino)pyrimidine (2.6 g) in methanol (27 ml) and 2N hydrochloric acid (6.9 ml) was left at room temperature for 24 hours and then heated on a steam bath for 30 minutes. The solvent was evaporated in vacuo and the residue re-crystallized twice from isopropanol to give 2-phenoxy-4-piperazinopyrimidine (1.5 g) characterized spectroscopically, and used directly.

Workup

  1. temperatureheated on a steam bath for 30 minutes
  2. customThe solvent was evaporated in vacuo
  3. customthe residue re-crystallized twice from isopropanol

Sources & evidence

ORD record
ord-9a553c30dfb84be5bbed5e7cf02aefd2
Source dataset
uspto-grants-1984_11
Patent number
US04483859

Reaction notes

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