Acetic Anhydride → 9-Acetoxy-3,4-diazatricyclo[4,2,1,02,5]nona-3,7-diene
Reaction equation
[OH:1][CH:2]1[CH:8]2[CH:9]=[CH:10][CH:3]1[CH:4]1[CH:7]2[N:6]=[N:5]1.[C:11](OC(=O)C)(=[O:13])[CH3:12].C(N(CC)CC)C>CCOCC>[C:11]([O:1][CH:2]1[CH:8]2[CH:9]=[CH:10][CH:3]1[CH:4]1[CH:7]2[N:6]=[N:5]1)(=[O:13])[CH3:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
5 parts of 9-hydroxy-3,4-diazatricyclo[4,2,1,02,5 ]nona-3,7-diene, 5 parts of acetic anhydride, 1 part of triethylamine and 100 parts of ether were refluxed for 24 hours, after which the reaction mixture was extracted twice with 50 parts of water, and the organic phase was dried with MgSO4 and evaporated down in a rotary evaporator to give 6.2 parts (95 mole %) of 9-acetoxy-3,4-diazatricyclo[4,2,1,02,5 ]nona-3,7-diene of melting point 58° C.
Workup
- extractionafter which the reaction mixture was extracted twice with 50 parts of water
- dry with materialthe organic phase was dried with MgSO4
- customevaporated down in a rotary evaporator
Sources & evidence
- ORD record
- ord-37b2695f948348a188a8a1879465d1f0
- Source dataset
- uspto-grants-1985_04
- Patent number
- US04512795
Reaction notes
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