HCID 68844381, compound → HCID 68843919, compound
Reaction equation
[CH3:1][N:2]1[C:9](=[O:10])[CH:8]2[N:11](C(OCC3C=CC=CC=3)=O)[CH:4]([CH2:5][CH2:6][CH2:7]2)[C:3]1=[O:22].[H][H]>C(OCC)(=O)C.[Pd]>[CH3:1][N:2]1[C:9](=[O:10])[CH:8]2[NH:11][CH:4]([CH2:5][CH2:6][CH2:7]2)[C:3]1=[O:22]Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
A stirred suspension of benzyl 3-methyl-2,4-dioxo-3,9-diazabicyclo[3.3.1]nonane-9-carboxylate (742 mg, 2.454 mmol) and 10% Pd—C (100 mg) in ethyl acetate (40 ml) was hydrogenated under balloon pressure of hydrogen overnight. The suspension was filtered to remove the catalyst and the filtrate was evaporated to dryness to afford 3-methyl-3,9-diazabicyclo[3.3.1]nonane-2,4-dione as a white solid (377 mg). MS: m/e 169 (MH+).
Workup
- filtrationThe suspension was filtered
- customto remove the catalyst
- customthe filtrate was evaporated to dryness
Sources & evidence
- ORD record
- ord-7e218f028c4e482cb111dd6c3561efd7
- Source dataset
- uspto-grants-2009_06
- Patent number
- US07547690B2
Reaction notes
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