Ammonium Chloride → 6-amino-4-fluoro-3-isopropyl-1,3-benzoxazol-2(3H)-one

HRID 1991347Notes

Reaction equation

HRID 1991347 reaction equation
[F:1][C:2]1[C:7]2[N:8]([CH:12]([CH3:14])[CH3:13])[C:9](=[O:11])[O:10][C:6]=2[CH:5]=[C:4]([N+:15]([O-])=O)[CH:3]=1.[Cl-].[NH4+]>C(O)C.O.[Fe]>[NH2:15][C:4]1[CH:3]=[C:2]([F:1])[C:7]2[N:8]([CH:12]([CH3:14])[CH3:13])[C:9](=[O:11])[O:10][C:6]=2[CH:5]=1

Participants

6

Reactant 2

HCID 25517Ammonium ChlorideHCID 68487872HCID 68487872, compound

Product 1

HCID 684896766-amino-4-fluoro-3-isopropyl-1,3-benzoxazol-2(3H)-one

Reagents, catalysts & solvents 3

HCID 23925IronCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Prepared from 4-fluoro-3-isopropyl-6-nitro-1,3-benzoxazol-2(3H)-one (Step 1, 0.87 g, 3.64 mmol), ammonium chloride (1.95 g, 36.4 mmol) and iron powder (0.81 g, 14.6 mmol) in ethanol (30 ml) and water (15 ml) according to the method of EXAMPLE 86, Step 7 (0.77 g, 99%).

Sources & evidence

ORD record
ord-ebe6659efd9d4d7a824fbaf7cdca53f9
Source dataset
uspto-grants-2010_01
Patent number
US07645781B2

Reaction notes

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