Hydrochloric Acid → 1-Ethyl-3-methyl-3,7-dihydro-purine-2,6-dione
Reaction equation
C(OC[N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH2:15][CH3:16])[C:10](=[O:17])[N:9]([CH3:18])[C:8]=2[N:7]=[CH:6]1)C.Cl>C(O)C>[CH2:15]([N:11]1[C:12](=[O:14])[C:13]2[NH:5][CH:6]=[N:7][C:8]=2[N:9]([CH3:18])[C:10]1=[O:17])[CH3:16]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
28.7 g (0.11 mol) of 7-ethoxymethyl-1-ethyl-3-methylxanthine were stirred at 60° C. for 60 hours in a solution of 200 ml of 5N hydrochloric acid and 200 ml of ethanol. The reaction mixture was concentrated to dryness and the residue which remained was crystallized in ethyl acetate/diisopropyl ether.
Workup
- concentrationThe reaction mixture was concentrated to dryness
- customthe residue which remained was crystallized in ethyl acetate/diisopropyl ether
Sources & evidence
- ORD record
- ord-1e4a1fe78dd64b49acf4eb3616e08f35
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05728686
Reaction notes
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