Hydrochloric Acid → 1-Ethyl-3-methyl-3,7-dihydro-purine-2,6-dione

HRID 1993

Reaction equation

HRID 1993 reaction equation
C(OC[N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH2:15][CH3:16])[C:10](=[O:17])[N:9]([CH3:18])[C:8]=2[N:7]=[CH:6]1)C.Cl>C(O)C>[CH2:15]([N:11]1[C:12](=[O:14])[C:13]2[NH:5][CH:6]=[N:7][C:8]=2[N:9]([CH3:18])[C:10]1=[O:17])[CH3:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 196891947-Ethoxymethyl-1-ethyl-3-methylxanthine

Product 1

HCID 129053881-Ethyl-3-methyl-3,7-dihydro-purine-2,6-dione

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

28.7 g (0.11 mol) of 7-ethoxymethyl-1-ethyl-3-methylxanthine were stirred at 60° C. for 60 hours in a solution of 200 ml of 5N hydrochloric acid and 200 ml of ethanol. The reaction mixture was concentrated to dryness and the residue which remained was crystallized in ethyl acetate/diisopropyl ether.

Workup

  1. concentrationThe reaction mixture was concentrated to dryness
  2. customthe residue which remained was crystallized in ethyl acetate/diisopropyl ether

Sources & evidence

ORD record
ord-1e4a1fe78dd64b49acf4eb3616e08f35
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Linked notes

Loading…