Sulfuric Acid → 2-Chloro-5-phenylpyrazine

HRID 1995060

Reaction equation

HRID 1995060 reaction equation
[C:1]1([C:7]2[N:8]=[CH:9][C:10](=O)[NH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O=P(Cl)(Cl)[Cl:16].S(=O)(=O)(O)O>>[Cl:16][C:10]1[CH:9]=[N:8][C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[CH:12][N:11]=1

Participants

4

Reactant 3

HCID 1118Sulfuric AcidHCID 24813Phosphorus oxychlorideHCID 5990375-phenyl-1H-pyrazin-2-one

Product 1

HCID 12366642-Chloro-5-phenylpyrazine

Procedure

A mixture of 0.01 mol. of 5-phenylpyrazin-2(1H)one 8.0 ml. of POCl3 and a drop of concentrated sulfuric acid is refluxed for 4-5 hr. The solution is poured into 100 g. of ice. The title compound is isolated by filtration and recrystallized.

Workup

  1. additionA mixture of 0.01 mol
  2. additionThe solution is poured into 100 g

Sources & evidence

ORD record
ord-2130e3284caf45838b838060e626ad40
Source dataset
uspto-grants-1983_09
Patent number
US04402958

Linked notes

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