Dichloromethane → Tasquinimod

HRID 199597

Reaction equation

HRID 199597 reaction equation
[CH3:19][CH2:20][N:21]([CH2:22][CH3:23])[CH2:24][CH3:25].[Cl:42][CH2:43][Cl:44].[F:26][C:27]([c:28]1[cH:29][cH:30][c:31]([NH:32][CH3:33])[cH:34][cH:35]1)([F:36])[F:37].[OH:1][c:2]1[c:3]([C:16](=[O:17])[OH:18])[c:4](=[O:15])[n:5]([CH3:14])[c:6]2[cH:7][cH:8][cH:9][c:10]([O:12][CH3:13])[c:11]12.[S:38]([Cl:39])([Cl:40])=[O:41]>>[OH:1][c:2]1[c:3]([C:16](=[O:18])[N:32]([c:31]2[cH:30][cH:29][c:28]([C:27]([F:26])([F:36])[F:37])[cH:35][cH:34]2)[CH3:33])[c:4](=[O:15])[n:5]([CH3:14])[c:6]2[cH:7][cH:8][cH:9][c:10]([O:12][CH3:13])[c:11]12

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 15099755N-Methyl-4-(trifluoromethyl)anilineHCID 547035823-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-5-methoxy-1-methyl-2-oxo-

Product 1

HCID 54682876Tasquinimod

Sources & evidence

ORD record
ord-59382d677b674f28908854d212470709
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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