Methyl iodide → 2,2-dimethyl-N-[2-methyl-3-(trifluoromethyl)phenyl]propanamide

HRID 199623

Reaction equation

HRID 199623 reaction equation
[CH3:18][CH2:19][CH2:20][CH2:21][Li:22].[CH3:1][C:2]([C:3](=[O:4])[NH:5][c:6]1[cH:7][c:8]([C:12]([F:13])([F:14])[F:15])[cH:9][cH:10][cH:11]1)([CH3:16])[CH3:17].[CH3:23][I:24].[O:25]1[CH2:26][CH2:27][CH2:28][CH2:29]1>>[CH3:1][C:2]([C:3](=[O:4])[NH:5][c:6]1[c:7]([CH3:18])[c:8]([C:12]([F:13])([F:14])[F:15])[cH:9][cH:10][cH:11]1)([CH3:16])[CH3:17]

Participants

5

Reactant 4

HCID 6328Methyl iodideHCID 8028TetrahydrofuranHCID 7143392,2-Dimethyl-n-[3-(trifluoromethyl)phenyl]propanamideHCID 178418339Butyllithium

Product 1

HCID 15126632,2-dimethyl-N-[2-methyl-3-(trifluoromethyl)phenyl]propanamide

Sources & evidence

ORD record
ord-62217f007dff4e469ab82282c04367f3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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