7-Benzyl-1-ethoxymethyl-3-methylxanthine → 1-Ethoxymethyl-3-methylxanthine

HRID 1997

Reaction equation

HRID 1997 reaction equation
C([N:8]1[C:16]2[C:15](=[O:17])[N:14]([CH2:18][O:19][CH2:20][CH3:21])[C:13](=[O:22])[N:12]([CH3:23])[C:11]=2[N:10]=[CH:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[CH2:20]([O:19][CH2:18][N:14]1[C:15](=[O:17])[C:16]2[NH:8][CH:9]=[N:10][C:11]=2[N:12]([CH3:23])[C:13]1=[O:22])[CH3:21]

Participants

4

Reactant 1

HCID 196891457-Benzyl-1-ethoxymethyl-3-methylxanthine

Product 1

HCID 98159381-Ethoxymethyl-3-methylxanthine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

17.5 g (0.056 mol) of 7-benzyl-1-ethoxymethyl-3-methylxanthine were hydrogenated over 1.8 g of palladium (10%) on activated carbon at room temperature for 8 hours in 500 ml of ethanol. The catalyst was filtered off and the filtrate was concentrated to dryness and crystallized from dimethylformamide/diisopropyl ether.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated to dryness
  3. customcrystallized from dimethylformamide/diisopropyl ether

Sources & evidence

ORD record
ord-8274ed2fb34e4d4d9f44b77cbe179a49
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Linked notes

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