Benzylamine → tert-butyl (3R,4R)-4-(benzylamino)-3-hydroxypiperidine-1-carboxylate
Reaction equation
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:14][C@@H:13]([C@H:11]2[CH2:10][CH2:9]1)[O:12]2)=[O:7])([CH3:4])[CH3:3].[NH2:15][CH2:16][c:17]1[cH:22][cH:21][cH:20][cH:19][cH:18]1>>[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:14][C@@H:13]([OH:12])[C@H:11]([NH:15][CH2:16][c:17]2[cH:22][cH:21][cH:20][cH:19][cH:18]2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3]Participants
6
Reactant 2
Product 1
Reagents, catalysts & solvents 3
Conditions
- Temperature
- 80 °C
Sources & evidence
- ORD record
- ord-6fbaa393b58146edbb7fee639e352eb9
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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