Benzylamine → tert-butyl (3R,4R)-4-(benzylamino)-3-hydroxypiperidine-1-carboxylate
Reaction equation
[NH2:1][CH2:2][c:3]1[cH:8][cH:7][cH:6][cH:5][cH:4]1.[CH3:9][C:10]([O:13][C:14]([N:16]1[CH2:22][C@@H:21]([C@H:19]2[CH2:18][CH2:17]1)[O:20]2)=[O:15])([CH3:12])[CH3:11]>>[CH3:9][C:10]([O:13][C:14]([N:16]1[CH2:22][C@@H:21]([OH:20])[C@H:19]([NH:1][CH2:2][c:3]2[cH:8][cH:7][cH:6][cH:5][cH:4]2)[CH2:18][CH2:17]1)=[O:15])([CH3:12])[CH3:11]Participants
6
Reactant 2
Product 1
Reagents, catalysts & solvents 3
Conditions
- Temperature
- 80 °C
Sources & evidence
- ORD record
- ord-5c0ee80ab4634cb69d9e0621697f442a
- Source dataset
- 39k HTE dataset from Pfizer
- Original link
- View source
Reaction notes
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