Chloroform → 4-Chloro-2-(2-fluorophenyl)thieno[2,3-d]pyrimidine

Reaction equation

[CH3:22][N:23]([CH3:24])[CH:25]=[O:26].[CH:27]([Cl:28])([Cl:29])[Cl:30].[F:1][c:2]1[c:3](-[c:8]2[nH:9][c:10](=[O:17])[c:11]3[c:12]([n:13]2)[s:14][cH:15][cH:16]3)[cH:4][cH:5][cH:6][cH:7]1.[S:18]([Cl:19])([Cl:20])=[O:21]>>[F:1][c:2]1[c:3](-[c:8]2[n:9][c:10]([Cl:20])[c:11]3[c:12]([n:13]2)[s:14][cH:15][cH:16]3)[cH:4][cH:5][cH:6][cH:7]1

Participants

Reactant 4

HCID 6212Chloroform

HCID 6228Dimethylformamide

HCID 24386Thionyl Chloride

HCID 211043032-(2-Fluoro-phenyl)-3H-thieno[2,3-d]pyrimidin-4-one

Product 1

HCID 211043364-Chloro-2-(2-fluorophenyl)thieno[2,3-d]pyrimidine

Sources & evidence

ORD record: ord-e4a9e75c7347454587d4c1673dcc4571
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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