Dimethylformamide → 6-(2-cyanophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]nicotinamide

HRID 201261

Reaction equation

HRID 201261 reaction equation
[C:1](#[N:2])[c:3]1[c:4](-[c:9]2[n:10][cH:11][c:12]([C:13](=[O:14])[OH:15])[cH:16][cH:17]2)[cH:5][cH:6][cH:7][cH:8]1.[CH3:30][N:31]([CH3:32])[CH:33]=[O:34].[F:18][C:19]([CH2:20][N:21]1[CH2:22][CH2:23][CH:24]([NH2:27])[CH2:25][CH2:26]1)([F:28])[F:29]>>[C:1](#[N:2])[c:3]1[c:4](-[c:9]2[n:10][cH:11][c:12]([C:13](=[O:15])[NH:27][CH:24]3[CH2:23][CH2:22][N:21]([CH2:20][C:19]([F:18])([F:28])[F:29])[CH2:26][CH2:25]3)[cH:16][cH:17]2)[cH:5][cH:6][cH:7][cH:8]1

Participants

4

Reactant 3

HCID 6228DimethylformamideHCID 162287221-(2,2,2-Trifluoroethyl)piperidin-4-amineHCID 672685396-(2-Cyanophenyl)nicotinic acid

Product 1

HCID 597438436-(2-cyanophenyl)-N-[1-(2,2,2-trifluoroethyl)piperidin-4-yl]nicotinamide

Sources & evidence

ORD record
ord-cad0fee173454a4a9b45ab3279ad01d4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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