Methyl 3,5-Dibromobenzoate → Methyl-3-bromo-5-(3-pyridyl)benzoate

HRID 2018664

Reaction equation

HRID 2018664 reaction equation

[CH3:1][O:2][C:3]([c:5]1[cH:11][c:10](Br)[cH:9][c:7]([Br:8])[cH:6]1)=[O:4].OB([c:12]1[cH:17][n:16][cH:15][cH:14][cH:13]1)O>>[CH3:1][O:2][C:3]([c:5]1[cH:11][c:10]([c:12]2[cH:17][n:16][cH:15][cH:14][cH:13]2)[cH:9][c:7]([Br:8])[cH:6]1)=[O:4]

Participants

7

Reactant 2

HCID 621923Methyl 3,5-Dibromobenzoate

HCID 27343783-Pyridinylboronic acid

Product 1

HCID 21942604Methyl-3-bromo-5-(3-pyridyl)benzoate

Reagents, catalysts & solvents 4

HCID 25953Cesium fluorideReagent

HCID 11979704Tetrakis(triphenylphosphine)palladiumCatalyst

HCID 887MethanolSolvent

HCID 117669-PhenylanthraceneInternal standard

Conditions

Temperature: 90 °C

Sources & evidence

ORD record: ord-d10d49c9d6ee4cc6b9659c89163002a5
Source dataset: 39k HTE dataset from Pfizer
DOI: 10.1038/s41557
Original link: View source

Linked notes

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