Dimethylformamide → 6-Methoxy-5-(trifluoromethyl)naphthalen-1-amine

Reaction equation

[CH3:1][O:2][c:3]1[c:4]([C:16]([F:17])([F:18])[F:19])[c:5]2[cH:6][cH:7][cH:8][c:9]([C:13]([OH:14])=[O:15])[c:10]2[cH:11][cH:12]1.[CH3:20][N:21]([CH3:22])[CH:23]=[O:24].[S:25]([Cl:26])([Cl:27])=[O:28]>>[CH3:1][O:2][c:3]1[c:4]([C:16]([F:17])([F:18])[F:19])[c:5]2[cH:6][cH:7][cH:8][c:9]([NH2:21])[c:10]2[cH:11][cH:12]1

Participants

Reactant 3

HCID 6228Dimethylformamide

HCID 24386Thionyl Chloride

HCID 132173011-Naphthalenecarboxylic acid, 6-methoxy-5-(trifluoromethyl)-

Product 1

HCID 141561656-Methoxy-5-(trifluoromethyl)naphthalen-1-amine

Sources & evidence

ORD record: ord-28250e474d3f40158a8b5cc9eb17b909
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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