Diethyl (3-bromopropyl)phosphonate → Diethyl [3-(3,7-dibutylxanthin-1-yl)propyl]phosphonate

HRID 2033

Reaction equation

HRID 2033 reaction equation
[CH2:1]([N:5]1[C:13]2[N:12]=[CH:11][N:10]([CH2:14][CH2:15][CH2:16][CH3:17])[C:9]=2[C:8](=[O:18])[NH:7][C:6]1=[O:19])[CH2:2][CH2:3][CH3:4].Br[CH2:21][CH2:22][CH2:23][P:24]([O:29][CH2:30][CH3:31])(=[O:28])[O:25][CH2:26][CH3:27]>>[CH2:1]([N:5]1[C:13]2[N:12]=[CH:11][N:10]([CH2:14][CH2:15][CH2:16][CH3:17])[C:9]=2[C:8](=[O:18])[N:7]([CH2:21][CH2:22][CH2:23][P:24](=[O:28])([O:29][CH2:30][CH3:31])[O:25][CH2:26][CH3:27])[C:6]1=[O:19])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 283500Diethyl (3-bromopropyl)phosphonateHCID 3507673,7-dibutyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

Product 1

HCID 22446269Diethyl [3-(3,7-dibutylxanthin-1-yl)propyl]phosphonate

Procedure

The title substance was prepared from 0.02 mol of 3,7-dibutylxanthine and 0.022 mol of diethyl 3-bromopropanephosphonate analogously to Example 23 and chromatographed on silica gel (eluent: dichloromethane/methanol 20:1).

Workup

  1. customchromatographed on silica gel (eluent: dichloromethane/methanol 20:1)

Sources & evidence

ORD record
ord-850bc9b85c9e4146b22bb952817275a6
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Linked notes

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