1-Methylpiperazine → 1-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

HRID 2036069

Reaction equation

HRID 2036069 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]([F:14])([F:13])[F:12].[CH3:15][N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1>CO.O>[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=2[C:11]([F:14])([F:13])[F:12])[CH2:18][CH2:17]1

Participants

5

Reactant 2

HCID 531671-MethylpiperazineHCID 949542-Fluoro-5-nitrobenzotrifluoride

Product 1

HCID 31280181-Methyl-4-[4-nitro-2-(trifluoromethyl)phenyl]piperazine

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

2-Fluoro-5-nitrobenzotrifluoride (2 g) and 1-methylpiperazine (2 mL) were dissolved in methanol (5 mL). The yellow solution was stirred at room temperature overnight. The reaction mixture was diluted with water (100 mL) and extracted with ethyl acetate (2×100 mL). The organic solutions were evaporated to give 2-(4-methylpiperazino)-5-nitrobenzotrifluoride.

Workup

  1. extractionextracted with ethyl acetate (2×100 mL)
  2. customThe organic solutions were evaporated

Sources & evidence

ORD record
ord-04933d5b4e924d9c87cedb20b88c8e38
Source dataset
uspto-grants-2013_11
Patent number
US08575165B2

Linked notes

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