Triphosgene → 5-Bromo-2-isocyanatomethyl-1,3-dimethyl-benzene

HRID 2036540Notes

Reaction equation

HRID 2036540 reaction equation
[Br:1][C:2]1[CH:9]=[C:8]([CH3:10])[C:5]([CH2:6][NH2:7])=[C:4]([CH3:11])[CH:3]=1.Cl[C:13](Cl)([O:15]C(=O)OC(Cl)(Cl)Cl)Cl.C1(C2(CC(O)(C)C)OC(=O)N([C@H](C3C=CC(C4C=CN(C)C(=O)C=4)=CC=3)C)CC2)CC1>>[Br:1][C:2]1[CH:3]=[C:4]([CH3:11])[C:5]([CH2:6][N:7]=[C:13]=[O:15])=[C:8]([CH3:10])[CH:9]=1

Participants

4

Reactant 3

HCID 94429TriphosgeneHCID 39872008(4-Bromo-2,6-dimethylphenyl)methanamineHCID 596356736-cyclopropyl-6-(2-hydroxy-2-methylpropyl)-3-((S)-1-(4-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)phenyl)ethyl)-1,3-oxazinan-2-one

Product 1

HCID 581023945-Bromo-2-isocyanatomethyl-1,3-dimethyl-benzene

Procedure

The title compound was prepared from 4-bromo-2,6-dimethyl-benzylamine and triphosgene following a procedure analogous to that described in Step 4 of Intermediate 1. Mass spectrum (EI): m/z=239/241 (Br) [M]+.

Sources & evidence

ORD record
ord-eb88cda7720b48c0b43ab2ae176ca16e
Source dataset
uspto-grants-2013_11
Patent number
US08575157B2

Reaction notes

Loading…