(Chloromethyl)cyclopropane → Diethyl [3-(7-cyclopropylmethyl-3-methylxanthin-1-yl)propyl]phosphonate
Reaction equation
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:11])[N:4]([CH2:12][CH2:13][CH2:14][P:15](=[O:22])([O:19][CH2:20][CH3:21])[O:16][CH2:17][CH3:18])[C:3]1=[O:23].Cl[CH2:25][CH:26]1[CH2:28][CH2:27]1>>[CH:26]1([CH2:25][N:7]2[C:6]3[C:5](=[O:11])[N:4]([CH2:12][CH2:13][CH2:14][P:15](=[O:22])([O:16][CH2:17][CH3:18])[O:19][CH2:20][CH3:21])[C:3](=[O:23])[N:2]([CH3:1])[C:10]=3[N:9]=[CH:8]2)[CH2:28][CH2:27]1Participants
3
Procedure
The title substance was prepared from 0.015 mol of diethyl [3-(3-methyl-xanthin-1-yl)propyl]phosphonate (Example 42), and 0.017 mol of chloromethylcyclopropane analogously to Example 30 and chromatographed on silica gel (eluent: dichloromethane/methanol 20:1).
Workup
- customchromatographed on silica gel (eluent: dichloromethane/methanol 20:1)