(Chloromethyl)cyclopropane → Diethyl [5-(7-cyclopropylmethyl-3-methylxanthin-1-yl)pentyl]phosphonate
Reaction equation
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][NH:7][C:6]=2[C:5](=[O:11])[N:4]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][P:17](=[O:24])([O:21][CH2:22][CH3:23])[O:18][CH2:19][CH3:20])[C:3]1=[O:25].Cl[CH2:27][CH:28]1[CH2:30][CH2:29]1>>[CH:28]1([CH2:27][N:7]2[C:6]3[C:5](=[O:11])[N:4]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][P:17](=[O:24])([O:21][CH2:22][CH3:23])[O:18][CH2:19][CH3:20])[C:3](=[O:25])[N:2]([CH3:1])[C:10]=3[N:9]=[CH:8]2)[CH2:30][CH2:29]1Participants
3
Procedure
The title substance was prepared from 0.011 mol of diethyl [5-(3-methyl-xanthin-1-yl)pentyl]phosphonate and 0.013 mol of chloromethylcyclo-propane analogously to Example 46.
Sources & evidence
- ORD record
- ord-6c4f2236d92e42d3ad896c3d86de7aab
- Source dataset
- uspto-grants-1998_03