Trifluoroacetic acid → (2R)-1-Phenoxy-2-propanamine
Reaction equation
C(OC([NH:8][C@@H:9]([CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH3:10])=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:10][C@@H:9]([NH2:8])[CH2:11][O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
Dissolve (R)-2-(tert-butoxycarbonylamino)-3-phenoxy-propane (340 mg, 1.35 mmol) in DCM (80 mL), add trifluoroacetic acid (35 mL), and stir at 0° C. for 2 h. Evaporate and purify by SCX chromatography to give the title compound as a colorless oil (186 mg, 91%). MS (ES+) m/z: 151 (M+H)+.
Workup
- customEvaporate
- custompurify by SCX chromatography
Sources & evidence
- ORD record
- ord-ce9f10e4d1a646c889159275db14a2e1
- Source dataset
- uspto-grants-2013_11
- Patent number
- US08580780B2
Reaction notes
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