Triethylamine → HCID 86661654, compound
Reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]([C:7]([F:10])([F:9])[F:8])([CH3:6])[CH2:4][OH:5].C(N(CC)CC)C.[CH3:20][S:21](Cl)(=[O:23])=[O:22]>C(Cl)Cl.O>[F:1][C:2]([F:11])([F:12])[C:3]([CH3:6])([C:7]([F:9])([F:8])[F:10])[CH2:4][O:5][S:21]([CH3:20])(=[O:23])=[O:22]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
To 2,2-bis(trifloromethyl)propanol (4.34 g, 22.1 mmol) in DCM (100 mL) at 0° C. add with stirring triethylamine (6.2 mL, 44 mmol) followed by methanesulfonyl chloride (2.6 mL, 33 mmol). After 15 min at 0° C. dilute with water and extract three times with EtOAc. Dry over anhydrous Na2SO4 and concentrate in vacuo to give the crude desired intermediate as a yellow oil (6.16 g, 100%).
Workup
- extractionextract three times with EtOAc
- dry with materialDry over anhydrous Na2SO4
- concentrationconcentrate in vacuo
Sources & evidence
- ORD record
- ord-48faed1e96e342d49fd09021c34c7843
- Source dataset
- uspto-grants-2013_11
- Patent number
- US08580780B2
Reaction notes
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