[Cl:1][C:2]1[C:15]([N:16]=[C:17]=S)=[C:14]([Cl:19])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8].[CH3:20][O:21][C:22](=[O:36])[C:23]1[CH:28]=[C:27]([NH2:29])[C:26]([NH2:30])=[N:25][C:24]=1[O:31][CH2:32][CH:33]([F:35])[F:34].C(Cl)CCl>CC#N.O>[Cl:1][C:2]1[C:15]([NH:16][C:17]2[NH:29][C:27]3[C:26]([N:30]=2)=[N:25][C:24]([O:31][CH2:32][CH:33]([F:35])[F:34])=[C:23]([C:22]([O:21][CH3:20])=[O:36])[CH:28]=3)=[C:14]([Cl:19])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8]A mixture of N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide (4.00 g, 12.6 mmol) and 5,6-diamino-2-(2,2-difluoro-ethoxy)-nicotinic acid methyl ester (3.10 g, 12.5 mmol, prepared according to WO2010/034799) in MeCN (30 ml) is stirred for 2.5 h, then EDC (2.75 g, 14.3 mmol) is added and it is stirred at reflux for 15 min. The mixture is diluted with water, concentrated and extracted with DCM. The organic phase is dried with MgSO4, filtered and concentrated.
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