Propionic anhydride → 2-Amino-4-ethyl-7-(4-fluoro-phenyl)-7,8-dihydro-6H-quinazolin-5-one
Reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][C:12](=O)[CH2:11][C:10](=[O:15])[CH2:9]2)=[CH:4][CH:3]=1.[NH2:16][C:17]1[N:26]=C(C)[C:24]2[C:23](=O)CC(C3C=CC(F)=CC=3)C[C:19]=2[N:18]=1.C(OC(=O)CC)(=O)CC>>[NH2:26][C:17]1[N:18]=[C:19]([CH2:24][CH3:23])[C:11]2[C:10](=[O:15])[CH2:9][CH:8]([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[CH2:13][C:12]=2[N:16]=1Participants
4
Procedure
The title compound was prepared from 5-(4-fluoro-phenyl)-cyclohexane-1,3-dione, following the procedure describing the synthesis of 2-amino-7-(4-fluoro-phenyl)-4-methyl-7,8-dihydro-6H-quinazolin-5-one (example 3/a stage 1, 2 and 3). Propionic anhydride was used instead of acetic anhydride in stage 1.