Lithium Carbonate → HCID 59370529, compound

Reaction equation

F[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=1.[OH:14][C@H:15]1[CH2:19][CH2:18][NH:17][C@H:16]1[CH3:20].C(=O)([O-])[O-].[Li+].[Li+]>>[OH:14][C@H:15]1[CH2:19][CH2:18][N:17]([C:2]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([C:10]([F:13])([F:12])[F:11])[CH:3]=2)[C@H:16]1[CH3:20]

Participants

Reactant 3

HCID 11125Lithium Carbonate

HCID 6050854-Fluoro-2-(trifluoromethyl)benzonitrile

HCID 54198127HCID 54198127, compound

Product 1

HCID 59370529HCID 59370529, compound

Procedure

Using 4-fluoro-2-(trifluoromethyl)benzonitrile (851 mg), (2S,3S)-3-hydroxy-2-methylpyrrolidine (5 mmol) and lithium carbonate (665 mg), the title compound was obtained as a colorless solid (yield: 630 mg) by an operation similar to that in Example 3.

Sources & evidence

ORD record: ord-6e9fa53cdda74db49c9f52e5f8b8695d
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08592452B2

Reaction notes

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