Hydrochloric Acid → Methyl 5-chloro-2,4-difluorobenzoate

Reaction equation

[Cl:1][C:2]1[C:3]([F:12])=[CH:4][C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].Cl.[CH3:14]O>>[Cl:1][C:2]1[C:3]([F:12])=[CH:4][C:5]([F:11])=[C:6]([CH:10]=1)[C:7]([O:9][CH3:14])=[O:8]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 887Methanol

HCID 148764175-Chloro-2,4-difluorobenzoic acid

Product 1

HCID 58042369Methyl 5-chloro-2,4-difluorobenzoate

Procedure

A solution of 5-chloro-2,4-difluorobenzoic acid (2.8 g, 15 mmol) in a solution of HCl in methanol (4 M, 10 mL) was stirred at 60° C. for 4 hours. The reaction was cooled down and the solvent was evaporated to afford the title compound, which was used for the next step without further purification.