Hydrochloric Acid → alpha-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid

HRID 2049217

Reaction equation

HRID 2049217 reaction equation
C[O:2][C:3](=[O:16])[CH:4]([NH2:15])[C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([CH2:12][O:13][CH3:14])[CH:6]=1.Cl>[OH-].[Na+]>[NH2:15][CH:4]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([CH2:12][O:13][CH3:14])[CH:6]=1)[C:3]([OH:16])=[O:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53644499(-)-alpha-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid methyl ester

Product 1

HCID 23329768alpha-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

(-)-α-Amino-4-hydroxy-3-(methoxymethyl)benzeneacetic acid methyl ester is dissolved in aqueous 1 N sodium hydroxide and the solution is stirred at 40°-50° C. for 1 hour. The solution is acidified with 6 N hydrochloric acid to a pH of 7. Evaporation of the solvent gives the title compound in a 90% overall yield.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-b8fa6cddf3bd42f9ada012b3c998fe07
Source dataset
uspto-grants-1980_04
Patent number
US04197240

Linked notes

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