p-Toluenesulfonic acid → Methyl 4-hydroxy-5-methylthiophene-3-carboxylate
Reaction equation
C([O:4][C:5]1[C:6]([C:11]([O:13][CH3:14])=[O:12])=[CH:7][S:8][C:9]=1[CH3:10])(=O)C.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[OH:4][C:5]1[C:6]([C:11]([O:13][CH3:14])=[O:12])=[CH:7][S:8][C:9]=1[CH3:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To methyl 4-acetoxy-5-methyl-3-thiophenecarboxylate (214 g) in methanol (250 ml) was added p-toluenesulphonic acid (2 g), and the solution stirred at room temperature for three days.
Sources & evidence
- ORD record
- ord-e46146cf46ee430f80de5d7a252f70e4
- Source dataset
- uspto-grants-1991_05
- Patent number
- US05015656
Reaction notes
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