Acetylacetone → 2,5,7-Trimethylpyrazolo[1,5-a]pyrimidine
Reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([CH3:7])[NH:4][N:3]=1.[C:8]([CH2:11][C:12](=O)[CH3:13])(=O)[CH3:9]>C(O)(C)C>[CH3:7][C:5]1[CH:6]=[C:2]2[N:1]=[C:8]([CH3:9])[CH:11]=[C:12]([CH3:13])[N:3]2[N:4]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 9.7 g of 3-amino-5-methylpyrazole, 13 ml of acetylacetone and 50 ml of isopropanol is heated under reflux for 3 hours. After distilling isopropanol off, the residue is dissolved in dichloromethane, washed with water and dried over anhydrous magnesium sulfate when chloroform is distilled off, 12.7 g of the title compound is obtained as crystals. mp. 70°-73° C.
Workup
- temperatureis heated
- temperatureunder reflux for 3 hours
- distillationAfter distilling isopropanol off, the residue
- dissolutionis dissolved in dichloromethane
- washwashed with water
- dry with materialdried over anhydrous magnesium sulfate when chloroform
- distillationis distilled off
Sources & evidence
- ORD record
- ord-cbdd7df021f24864a7fd27b6ce766633
- Source dataset
- uspto-grants-1991_05
- Patent number
- US05017212
Reaction notes
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