Water → benzenesulfonamide, n-2-pyridinyl-

HRID 2052542

Reaction equation

HRID 2052542 reaction equation
[S:1](Cl)([OH:4])(=O)=[O:2].[CH:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1.O>O1CCCC1>[C:6]1([S:1]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)(=[O:4])=[O:2])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

Participants

5

Reactant 3

HCID 962WaterHCID 104392-AminopyridineHCID 22564087Benzene sulphochloride

Product 1

HCID 261514benzenesulfonamide, n-2-pyridinyl-

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 264 g of benzene sulphochloride was added dropwise at 10° to 25° C. to a solution of 282 g of 2-aminopyridine in 1200 ml of tetrahydrofuran. After two hours continuous stirring without further cooling, the mixture was poured into water. The reaction product was suction filtered and washed first with water and then with methanol.

Workup

  1. filtrationfiltered
  2. washwashed first with water

Sources & evidence

ORD record
ord-3eeb4aaf21c44523984185ff1c34f48c
Source dataset
uspto-grants-1980_01
Patent number
US04186019

Linked notes

Loading…