2-Chloroacetophenone → 1-Phenyl-2-(piperazin-1-yl)ethan-1-one dihydrochloride
Reaction equation
[CH:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)=O.[Cl:9]C[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[ClH:9].[ClH:9].[CH2:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of N-formyl piperazine (20 g, 175 mmol), 2-chloro-1-phenylethanone (32.5 g, 210 mmol) and K2CO3 (36 g, 262 mmol) in 180 ml of acetone was treated according to the general preparation 1 to give N-phenacyl piperazine dihydrochloride, 28 g (57%), mp 246-8° C. (dec).
Workup
- additionwas treated
- customaccording to the general preparation 1
Sources & evidence
- ORD record
- ord-c1ebb71f5a664fc7a5922ddadb654373
- Source dataset
- uspto-grants-2008_02
- Patent number
- US07326710B2
Reaction notes
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