Hydrochloric Acid → {4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride

HRID 2054693

Reaction equation

HRID 2054693 reaction equation
[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][N:20]=3)=[O:18])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1>CC(C)=O.CCOCC>[ClH:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][N:14]([C:17]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][N:20]=3)=[O:18])[CH2:13][CH2:12]2)=[CH:5][CH:4]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 9885359{4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone

Product 1

HCID 131726767{4-[2-(4-Fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 3283Diethyl EtherSolvent

Procedure

For salt formation, 1N hydrochloric acid is added to a solution of {4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone in 60 ml of acetone and 50 ml of ether until crystals form. When crystallisation is complete, the mother liquor is filtered off, and the precipitate is washed with ether and dried, giving {4-[2-(4-fluorophenyl)ethyl]piperazin-1-yl}isoquinolin-1-ylmethanone, hydrochloride, m.p. 238-240°.

Workup

  1. customform
  2. customWhen crystallisation
  3. filtrationthe mother liquor is filtered off
  4. washthe precipitate is washed with ether
  5. customdried

Sources & evidence

ORD record
ord-d0a23f68871b41f4a282286bf96a4ab9
Source dataset
uspto-grants-2008_02
Patent number
US07329749B2

Linked notes

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