4'-Chloroacetyl(acetanilide) → HCID 69055552, compound

HRID 2055223Notes

Reaction equation

HRID 2055223 reaction equation
[ClH:1].Cl.[N+:3]([C:6]1[CH:18]=[CH:17][C:9]([CH2:10][N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[CH:8][CH:7]=1)([O-:5])=[O:4].[Cl:19][CH2:20][C:21]([C:23]1[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:32])[CH3:31])=[CH:25][CH:24]=1)=[O:22].C([O-])([O-])=O.[K+].[K+]>>[ClH:19].[ClH:1].[N+:3]([C:6]1[CH:18]=[CH:17][C:9]([CH2:10][N:11]2[CH2:16][CH2:15][N:14]([CH2:20][C:21]([C:23]3[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:32])[CH3:31])=[CH:25][CH:24]=3)=[O:22])[CH2:13][CH2:12]2)=[CH:8][CH:7]=1)([O-:5])=[O:4]

Participants

4

Reactant 3

HCID 88054'-Chloroacetyl(acetanilide)HCID 11430Potassium CarbonateHCID 180056791-(4-Nitrobenzyl)piperazine dihydrochloride

Product 1

HCID 69055552HCID 69055552, compoundYield 74%

Procedure

A mixture of N-(4-nitrobenzyl)piperazine dihydrochloride (2.94 g, 10 mmol), N-[4-(2-chloroacetyl)phenyl]acetamide (2.37 g, 12 mmol) and anhydrous K2CO3 (4.83 g, 35 mmol) was treated according to general preparation 2 to give compound (IV-18), yield 74%, mp 228-230° C. M+ 396.

Workup

  1. additionwas treated
  2. customaccording to general preparation 2
  3. customto give compound (IV-18), yield 74%, mp 228-230° C

Sources & evidence

ORD record
ord-65e0a3f8c5474fbca21d3a8790b9e5ef
Source dataset
uspto-grants-2008_02
Patent number
US07332495B2

Reaction notes

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