Hydrochloric Acid → 3-(Pyridin-4-yl)propanoic acid

HRID 2055324

Reaction equation

HRID 2055324 reaction equation
C([NH:4][C:5]1[CH:17]=[CH:16][C:8]2SC3C=CC=[CH:12][C:11]=3[C:7]=2[CH:6]=1)(=O)C.[OH-:18].[K+].Cl.[OH2:21]>C(O)C>[N:4]1[CH:5]=[CH:6][C:7]([CH2:8][CH2:16][C:17]([OH:21])=[O:18])=[CH:11][CH:12]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 1086272-Acetamidodibenzothiophene

Product 1

HCID 2332433-(Pyridin-4-yl)propanoic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 3-pyridin-4-ylpropanoate (Method 2; 103.1 g, 576 mnaol) in water (400 ml) and ethanol (20 ml) at room temperature was added potassium hydroxide (60 g, 1600 mmol). After 18 hours hydrochloric acid (100 ml) was added to give a white solid. Yield 62.8 g (73%). NMR 8.38 (d, 2H), 7.21 (d, 2H), 2.70 (t, 2H), 2.52 (t, 2H); m/z 152.2.

Workup

  1. customto give a white solid

Sources & evidence

ORD record
ord-82f2f0d528194f709d6abe2a07e30874
Source dataset
uspto-grants-2008_02
Patent number
US07332492B2

Linked notes

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