Imidazole → 1-Cyclooctylmethylimidazole

HRID 2058442Notes

Reaction equation

HRID 2058442 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[Na].Br[CH2:8][CH:9]1[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>C(O)C>[CH:9]1([CH2:8][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

5

Reactant 3

HCID 795ImidazoleHCID 5360545SodiumHCID 18459730(Bromomethyl)cyclooctane

Product 1

HCID 205502381-Cyclooctylmethylimidazole

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Imidazole (2.0 g, 0.03 mol) was added to a solution of sodium (0.7 g, 0.03 mol) in dry ethanol (50 ml). The mixture was stirred and heated to boiling when bromomethylcyclooctane (5.5 g, 0.027 mol) was added dropwise. Following the addition, the reaction mixture was stirred and boiled for 15 h.

Workup

  1. temperatureheated
  2. additionwas added dropwise
  3. additionthe addition
  4. stirringthe reaction mixture was stirred

Sources & evidence

ORD record
ord-17299225e1134e1b85d1cdd3e88ce6e3
Source dataset
uspto-grants-1982_03
Patent number
US04317830

Reaction notes

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