Hydrochloric Acid → 1-Cyclooctylmethylimidazole hydrochloride

HRID 2058450Notes

Reaction equation

HRID 2058450 reaction equation
[CH:1]1([CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:15]>CCOCC>[ClH:15].[CH:1]1([CH2:9][N:10]2[CH:14]=[CH:13][N:12]=[CH:11]2)[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 205502381-Cyclooctylmethylimidazole

Product 1

HCID 205502551-Cyclooctylmethylimidazole hydrochloride

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1-Cyclooctylmethylimidazole (~0.3 g) was dissolved in dry ether (30 ml), when a stream of dry hydrogen chloride was passed through the solution at -20° C. The resulting white precipitate was filtered off under dry nitrogen and recrystallised from ethyl acetate/petroleum ether (b.p. 40°-60° C.) to afford 1-cyclooctylmethylimidazole hydrochloride as a white solid, m.p. 20°-22° C.

Workup

  1. customwas passed through the solution at -20° C
  2. filtrationThe resulting white precipitate was filtered off under dry nitrogen
  3. customrecrystallised from ethyl acetate/petroleum ether (b.p. 40°-60° C.)

Sources & evidence

ORD record
ord-5bdd3835cb974ba2bc4d7b9ee7b35fb0
Source dataset
uspto-grants-1982_03
Patent number
US04317830

Reaction notes

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