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3-Quinolinecarboxaldehyde → HCID 178516883, compound

HRID 2060338
Notes
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Reaction equation

HRID 2060338 reaction equation
[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[N:3]=[CH:2]1.[N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:14]=[C:13]([CH:21]=O)[CH:12]=1.C([O:25][C:26](=O)[C:27](=[O:38])[CH2:28][C:29]1[C:37]2[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=2)[NH:31][CH:30]=1)C>C(O)C>[NH:1]1[C:5]2[CH:6]=[CH:7][C:8]([N:10]3[CH:21]([C:13]4[CH:12]=[N:11][C:20]5[C:15]([CH:14]=4)=[CH:16][CH:17]=[CH:18][CH:19]=5)[C:28]([C:29]4[C:37]5[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=5)[NH:31][CH:30]=4)=[C:27]([OH:38])[C:26]3=[O:25])=[CH:9][C:4]=2[N:3]=[CH:2]1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 836413-QuinolinecarboxaldehydeHCID 12457675HCID 12457675, compoundHCID 178507353HCID 178507353, compound

Product 1

HCID 178516883HCID 178516883, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

1H-Benzoimidazol-5-ylamine (1 mmol) and Quinoline-3-carbaldehyde (1 mmol) were added to ethanol (5 ml). After 30 min 3-(1H-Indol-3-yl)-2-oxo-propionic acid ethyl ester (1 mmol) was added. The reaction was heated to 50° C. and stirred for 24 h. After evaporation of the solvent the residue was purified with chromatographic methods.

Workup

  1. customAfter evaporation of the solvent the residue
  2. customwas purified with chromatographic methods

Sources & evidence

ORD record
ord-c11fc773ed9a42b4a0eac3c47e1ce7fe
Source dataset
uspto-grants-2012_10
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US08278345B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes