p-METHYLACETOPHENONE → N-(1-p-Tolyl-ethylidene)-N'-(2-trifluoromethyl-quinazolin-4-yl)-hydrazine

HRID 2063591

Reaction equation

[F:1][C:2]([F:16])([F:15])[C:3]1[N:12]=[C:11]([NH:13][NH2:14])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1.[CH3:17][C:18]1[CH:23]=[CH:22][C:21]([C:24](=O)[CH3:25])=[CH:20][CH:19]=1>>[C:18]1([CH3:17])[CH:23]=[CH:22][C:21]([C:24](=[N:14][NH:13][C:11]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[N:4]=[C:3]([C:2]([F:1])([F:15])[F:16])[N:12]=2)[CH3:25])=[CH:20][CH:19]=1

Participants

Reactant 2

HCID 8500p-METHYLACETOPHENONE

HCID 14754644-Hydrazino-2-(trifluoromethyl)quinazoline

Product 1

HCID 84890440N-(1-p-Tolyl-ethylidene)-N'-(2-trifluoromethyl-quinazolin-4-yl)-hydrazine

Procedure

The title compound was prepared from (2-trifluoromethyl-quinazolin-4-yl)-hydrazine (250 mg, 1.1 mmol) and 4′-methylacetophenone (0.22 mL, 1.6 mmol) by a procedure similar to Example 1, step 4 yielding 225 mg (60%) of a yellow solid. HPLC Purity: 95%.

Sources & evidence

ORD record: ord-11c0bab9bdb44b1396a859d1e188a678
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288398B2

Linked notes

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