Hydrazine hydrate (1:1) → 6-(4-Chlorophenyl)-4,5-Dihydropyridazin-3(2H)-One
Reaction equation
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH2:8][CH2:9][C:10](O)=[O:11])=O)=[CH:4][CH:3]=1.O.[NH2:16][NH2:17]>C(O)C>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]2[CH2:8][CH2:9][C:10](=[O:11])[NH:16][N:17]=2)=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 3-(4-chlorobenzoyl)propionic acid (20 g) in absolute ethanol (200 ml) was added 5 g of hydrazine monohydrate. A thick solid was formed which dissolved after heating. The resulting solution was refluxed for 3 h, cooled and the solid formed filtered and dried to yield 16 g (80%) of 6-(4-chlorophenyl)-4,5-dihydropyridazinone.
Workup
- customA thick solid was formed which
- dissolutiondissolved
- temperatureafter heating
- temperatureThe resulting solution was refluxed for 3 h
- temperaturecooled
- customthe solid formed
- filtrationfiltered
- customdried
Sources & evidence
- ORD record
- ord-81fec9f4834b4c55afc33fdf0315e395
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05728694
Reaction notes
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