Thioacetamide → 2-Methyl-5-m-tolyl-thiazole-4-carboxylic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5](Cl)[C:6]1[CH:7]=[C:8]([CH3:12])[CH:9]=[CH:10][CH:11]=1.[C:16]([NH2:19])(=[S:18])[CH3:17]>>[CH3:1][O:2][C:3]([C:4]1[N:19]=[C:16]([CH3:17])[S:18][C:5]=1[C:6]1[CH:7]=[C:8]([CH3:12])[CH:9]=[CH:10][CH:11]=1)=[O:15]Participants
3
Procedure
prepared by reaction of 3-Chloro-2-oxo-3-m-tolyl-propionic acid methyl ester with thioacetamide. LC-MS: tR=0.98 min; [M+H]+=248.5.
Sources & evidence
- ORD record
- ord-22f87dd9df0a4a73b6a2000c9bf82ac3
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08288429B2
Reaction notes
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