Thioacetamide → 2-Methyl-5-(3-trifluoromethyl-phenyl)-thiazole-4-carboxylic acid methyl ester
Reaction equation
[CH3:1][O:2][C:3](=[O:18])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1.[C:19]([NH2:22])(=[S:21])[CH3:20]>>[CH3:1][O:2][C:3]([C:4]1[N:22]=[C:19]([CH3:20])[S:21][C:5]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]([F:15])([F:14])[F:13])[CH:7]=1)=[O:18]Participants
3
Procedure
prepared by reaction of 3-chloro-2-oxo-3-(3-trifluoromethyl-phenyl)-propionic acid methyl ester with thioacetamide. LC-MS: tR=0.98 min; [M+H]+=302.2.
Sources & evidence
- ORD record
- ord-b4e7c23659124336b5c1922c647c0c06
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08288429B2
Reaction notes
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