Thioacetamide → 5-(4-Bromo-phenyl)-2-methyl-thiazole-4-carboxylic Acid Methyl Ester
Reaction equation
[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5]([C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=1)Cl.[C:16]([NH2:19])(=[S:18])[CH3:17]>>[CH3:1][O:2][C:3]([C:4]1[N:19]=[C:16]([CH3:17])[S:18][C:5]=1[C:7]1[CH:12]=[CH:11][C:10]([Br:13])=[CH:9][CH:8]=1)=[O:15]Participants
3
Procedure
prepared by reaction of 3-(4-bromo-phenyl)-3-chloro-2-oxo-propionic acid methyl ester with thioacetamide. LC-MS: tR=0.95 min; [M+H]+=312.1.
Sources & evidence
- ORD record
- ord-9a377b36439c4b1fa116cc9851053692
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08288435B2
Reaction notes
Loading…