Methoxyacetic Acid → 2-Methoxymethyl-5-phenyl-oxazole-4-carboxylic acid

HRID 2065092Notes

Reaction equation

[CH:1]1[CH:6]=[CH:5][C:4]([CH:7]([OH:13])[CH:8]([NH2:12])[C:9]([OH:11])=[O:10])=[CH:3][CH:2]=1.[CH3:14][O:15][CH2:16][C:17](O)=O>>[CH3:14][O:15][CH2:16][C:17]1[O:13][C:7]([C:4]2[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=2)=[C:8]([C:9]([OH:11])=[O:10])[N:12]=1

Participants

Reactant 2

HCID 12251Methoxyacetic Acid

HCID 94134DL-Phenylserine

Product 1

HCID 669285712-Methoxymethyl-5-phenyl-oxazole-4-carboxylic acid

Procedure

Prepared starting from DL-3-phenylserine hydrate following sequentially general procedures Y, Z with methoxyacetic acid, Z1 and Z2. LC-MS-conditions 02: tR=0.81 min; [M+H]+=234.45.

Workup

customPrepared

Sources & evidence

ORD record: ord-09a54b2e70494939a8fd1dcdec6c97cd
Source dataset: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08288419B2

Reaction notes

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