Diisopropylamine → 1-Bromo-3-chloro-2,4-difluorobenzene

HRID 206557

Reaction equation

HRID 206557 reaction equation
[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[CH2:8]([Li:9])[CH2:10][CH2:11][CH3:12].[CH:1]([NH:2][CH:3]([CH3:4])[CH3:5])([CH3:6])[CH3:7].[Cl:22][C:23]([Cl:24])([Cl:25])[C:26]([C:27]([Cl:28])([Cl:29])[Cl:30])=[O:31].[F:13][c:14]1[c:15]([Br:21])[cH:16][cH:17][c:18]([F:20])[cH:19]1>>[F:13][c:14]1[c:15]([Br:21])[cH:16][cH:17][c:18]([F:20])[c:19]1[Cl:22]

Participants

6

Reactant 5

HCID 7912DiisopropylamineHCID 8028TetrahydrofuranHCID 8303HexachloroacetoneHCID 676741-Bromo-2,4-difluorobenzeneHCID 178418339Butyllithium

Product 1

HCID 27732561-Bromo-3-chloro-2,4-difluorobenzene

Sources & evidence

ORD record
ord-d6957ad815d640df890695f58327c9c6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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