3-Hydroxyacetophenone → 3-[1-Hydroxy-1-(3-methylphenyl)ethyl]phenol
Reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[C:11]1([CH3:19])[CH:16]=[CH:15][CH:14]=[C:13]([Mg]Cl)[CH:12]=1>O1CCCC1>[OH:10][C:8]([C:4]1[CH:3]=[C:2]([OH:1])[CH:7]=[CH:6][CH:5]=1)([C:13]1[CH:14]=[CH:15][CH:16]=[C:11]([CH3:19])[CH:12]=1)[CH3:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
By using 3′-hydroxyacetophenone (200 mg) and a 1 M solution of m-tolylmagnesium chloride in tetrahydrofuran (4.4 ml) as starting materials, the title compound (329.0 mg) was obtained in the same manner as that of Reference Example 69.
Sources & evidence
- ORD record
- ord-5c2c6b537f004105b562a6d65d56be2d
- Source dataset
- uspto-grants-2012_10
- Patent number
- US08293715B2
Reaction notes
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