Diethyl Ether → 1-Piperidin-4-yl-1,3-dihydro-2H-indol-2-one

HRID 207006

Reaction equation

HRID 207006 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:15](=[O:23])[CH2:16][c:17]3[cH:18][cH:19][cH:20][cH:21][c:22]32)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH3:34][CH2:35][O:36][CH2:37][CH3:38].[Cl:31][CH2:32][Cl:33].[F:24][C:25]([F:26])([F:27])[C:28]([OH:29])=[O:30]>>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:15](=[O:23])[CH2:16][c:17]3[cH:18][cH:19][cH:20][cH:21][c:22]32)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67472855tert-Butyl 4-(2-oxo-2,3-dihydro-1H-indol-1-yl)piperidine-1-carboxylate

Product 1

HCID 27611521-Piperidin-4-yl-1,3-dihydro-2H-indol-2-one

Sources & evidence

ORD record
ord-f4dae117d3344f98b07485f2ac57e958
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Linked notes

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