Toluene → Dimethyl-bis(2-methyl-1H-inden-1-yl)silane

HRID 2070697

Reaction equation

HRID 2070697 reaction equation
[CH3:1][C:2]1[CH2:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.[C:11]1([CH3:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[CH2:18]([Li])[CH2:19][CH2:20]C.[CH3:23][Si:24]([CH3:27])(Cl)Cl>O.C1COCC1>[CH3:23][Si:24]([CH3:27])([CH:18]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:17]=[C:19]1[CH3:20])[CH:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH:10]=[C:2]1[CH3:1]

Participants

7

Reactant 4

HCID 1140TolueneHCID 6398DichlorodimethylsilaneHCID 165871H-Indene, 2-methyl-HCID 178418339Butyllithium

Product 1

HCID 4050248Dimethyl-bis(2-methyl-1H-inden-1-yl)silane

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
80 °C

Procedure

8.0 g (61.4 mmoles) of 2-methylindene were introduced into 175 mL of toluene and 13 mL of THF, and 24.6 mL of n-butyllithium (2.5 Min toluene) were added without interruption at room temperature. After this addition was complete, the mixture was heated to 80° C. and stirred at this temperature for one hour. It was allowed to cool to 40° C., then 3.96 g (30.7 mmoles) of dimethyldichlorosilane were slowly added dropwise. After this addition, the reaction solution was stirred for three hours at 60° C. and then overnight at room temperature. 70 mL of water were added and the phases that form were separated. The organic phase was washed with 100 mL of water, and the aqueous phase was extracted three times with a total of 100 mL of toluene. The combined organic phases were dried over magnesium sulfate. After separation of the magnesium sulfate, the solvent was removed and the residue was purified by column chromatography. The desired product was isolated in a yield of 8.16 g (84%) (purity 99%).

Workup

  1. additionwere added without interruption at room temperature
  2. additionAfter this addition
  3. temperatureto cool to 40° C.
  4. additionAfter this addition
  5. stirringthe reaction solution was stirred for three hours at 60° C.
  6. customovernight
  7. customat room temperature
  8. customthe phases that form were separated
  9. washThe organic phase was washed with 100 mL of water
  10. extractionthe aqueous phase was extracted three times with a total of 100 mL of toluene
  11. dry with materialThe combined organic phases were dried over magnesium sulfate
  12. customAfter separation of the magnesium sulfate
  13. customthe solvent was removed
  14. customthe residue was purified by column chromatography

Sources & evidence

ORD record
ord-e578723e9e7f4039a4b6fadaa31fb67f
Source dataset
uspto-grants-2012_10
Patent number
US08299287B2

Linked notes

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