Diphenyl Ether → HCID 12736928, compound
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][CH:9]=[C:8]([NH:11][C:12](=[CH:17][C:18]([O:20]C)=O)[C:13]([O:15][CH3:16])=[O:14])[C:7](=[O:22])[C:6]=2[CH:23]=1.C1(OC2C=CC=CC=2)C=CC=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:10][C:9]3[C:18](=[O:20])[CH:17]=[C:12]([C:13]([O:15][CH3:16])=[O:14])[NH:11][C:8]=3[C:7](=[O:22])[C:6]=2[CH:23]=1Participants
3
Procedure
Dimethyl 2-[(6-chloro-4-oxo-4H-1-benzopyran-3-yl)amino]-2-butenedioate (1.0 g, 0.0033 mole) was added to diphenyl ether (25 ml) at 200°. The reaction mixture was refluxed for 10 min. (bath temperature 260°-280°). The product, which crystallized out on cooling, was filtered off and washed with ether. Recrystallization from DMF gave white crystals (0.8 g, 88%), m.p. 300°-305°.
Workup
- temperatureThe reaction mixture was refluxed for 10 min. (bath temperature 260°-280°)
- customThe product, which crystallized out
- temperatureon cooling
- filtrationwas filtered off