Hydrochloric Acid → 1-[(1,2,3,4-Tetrahydro-1-oxo-2-naphthalenyl)-methyl]-4-anilino isonipecotamide, hydrochloride
Reaction equation
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH:3]1[CH2:12][N:13]1[CH2:21][CH2:20][C:16]([NH:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([C:17]([NH2:19])=[O:18])[CH2:15][CH2:14]1.[ClH:29]>C(O)C>[ClH:29].[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][CH2:4][CH:3]1[CH2:12][N:13]1[CH2:21][CH2:20][C:16]([NH:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)([C:17]([NH2:19])=[O:18])[CH2:15][CH2:14]1Participants
4
Procedure
Finely-ground 1-[(1,2,3,4-tetrahydro-1-oxo-2-naphthalenyl)-methyl]-4-anilino isonipecotamide (5.0 g) is slurried in absolute ethanol and treated with 1.2 equivalents of ethereal hydrogen chloride. The resulting mixture is cooled and filtered to yield the title compound.